PRED_PPI: a server for predicting protein-protein interactions based on sequence data with probability assignment
نویسندگان
چکیده
منابع مشابه
SPPS: A Sequence-Based Method for Predicting Probability of Protein-Protein Interaction Partners
BACKGROUND The molecular network sustained by different types of interactions among proteins is widely manifested as the fundamental driving force of cellular operations. Many biological functions are determined by the crosstalk between proteins rather than by the characteristics of their individual components. Thus, the searches for protein partners in global networks are imperative when attem...
متن کاملPredicting protein-protein interactions based only on sequences information.
Protein-protein interactions (PPIs) are central to most biological processes. Although efforts have been devoted to the development of methodology for predicting PPIs and protein interaction networks, the application of most existing methods is limited because they need information about protein homology or the interaction marks of the protein partners. In the present work, we propose a method ...
متن کاملPredicting Functional Protein-Protein Interactions Based on Computational Methods
Protein-protein interactions play a crucial role in the cellular process. In recent years, yet new experimental techniques have been developed to discover the protein-protein interaction networks, the accuracy and coverage has still proven to be limited. Computational approaches come into being essential both to assist in the design and validation of experimental studies and for the prediction ...
متن کاملAn Ensemble Classifier with Random Projection for Predicting Protein–Protein Interactions Using Sequence and Evolutionary Information
Identifying protein–protein interactions (PPIs) is crucial to comprehend various biological processes in cells. Although high-throughput techniques generate many PPI data for various species, they are only a petty minority of the entire PPI network. Furthermore, these approaches are costly and time-consuming and have a high error rate. Therefore, it is necessary to design computational methods ...
متن کاملKernel methods for predicting protein-protein interactions
MOTIVATION Despite advances in high-throughput methods for discovering protein-protein interactions, the interaction networks of even well-studied model organisms are sketchy at best, highlighting the continued need for computational methods to help direct experimentalists in the search for novel interactions. RESULTS We present a kernel method for predicting protein-protein interactions usin...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2010
ISSN: 1756-0500
DOI: 10.1186/1756-0500-3-145